REANIMA is supported over 5 years by €8 million funding from the European Union’s Horizon 2020 Programme
Heart Failure is a main cause of death and morbidity worldwide and is caused in many cases by the poor regenerative ability of the adult mammalian myocardium. REANIMA aims to prevent heart failure by reawakening the endogenous regenerative ability of the mammalian heart. We run a translational effort spanning from the evolution of natural regenerative abilities in different animals, to preclinical trials for innovative therapies.
is the leading cause of death in the world.
Heart failure is a worldwide epidemic that imposes a heavy societal burden in death, disease, and escalating economic costs and can only be resolved by heart transplantation.
The inability of the human heart to regenerate myocardium lost during a heart attack is the major factor in a high proportion of cases of heart failure.
To resolve this problem, Dr Torres said that “the goal of REANIMA is to provide new therapies for heart regeneration.”
Until now, clinical trials based on the introduction of stem cells into the heart have not shown regenerative capacity.
However, studies of spontaneous and induced heart regeneration in animal models suggest that the path to progress lies in the reactivation of endogenous regenerative mechanisms. Fish and amphibians are able to regenerate their hearts, and although mammals have historically been considered to lack this capacity, regeneration was recently shown to occur in injured hearts of newborn mice.
Unfortunately, in adult mammals, including humans, the heart’s residual capacity to regenerate is insufficient to recover function naturally.
Meet our Scientific Teams
- Nowoshilow S, Schloissnig S, …, Tanaka EM, Myers EM (2017). The axolotl genome and the evolution of key tissue formation regulators. Nature. 554(7690):50-55.
- Oliveira CR, …, Tanaka EM. (2017) Pseudotyped baculovirus is an effective gene expression tool for studying molecular function during axolotl limb regeneration. Dev Biol S0012-1606(17)30438-4
- Fei JF, Schuez M, …, Tanaka EM. (2017). Efficient gene knockin in axolotl and its use to test the role of satellite cells in limb regeneration. . Proc Natl Acad Sci U S A 114:12501-12506.
- Currie JD, Kawaguchi A …, Tanaka EM. (2016). Live Imaging of Axolotl Digit Regeneration Reveals Spatiotemporal Choreography of Diverse Connective Tissue Progenitor Pools. Dev Cell 39:411-423.
- Nacu E, Shabanova E, …, Tanaka EM. (2016). SHH and FGF8 substitute anterior/posterior tissue interactions to induce limb regeneration. Nature 533:407-410.
- Gabisonia, K., Prosdocimo, G., Aquaro, G.D., Carlucci, L., Zentilin, L., Secco, I., Ali, A., Braga, L., Gorgodze, N., Bernini, F., Burchielli, S., Collesi, C., Zandonà, L., Sinagra, G., Piacenti, M., Zacchigna, S., Bussani, R., Recchia, F.A., Giacca, M. (2019). MicroRNA therapy stimulates uncontrolled cardiac repair after myocardial infarction in pigs. Nature, in press
All the REANIMA project publications.
To read the full list
Leipzig’s Institute for Clinical Immunology: Special diagnostics and modern treatments Immunology is an exciting and relatively new medical field that deals with the basics of
Elly Tanaka receives the award for her pioneering work developing a molecular understanding of limb and spinal cord regeneration. She developed new methods to study
Neurimmune AG and Ethris GmbH announced today an exclusive partnership to develop mRNA-encoded, neutralizing anti-SARS-CoV-2 antibodies administered by inhalation for the treatment of Covid-19. Companies
Scientists from the Faculty of Life Sciences & Medicine have been working to screen drugs that could have the potential to target the COVID-19 virus.
The Academia de Ciencias de América Latina, ACAL has appointed Dr. Miguel Torres as a Honorary Member in recognition of the high level scientific activity,
Dr. Miguel Torres, of the Centro Nacional de Investigaciones Cardiovasculares (CNIC), leads a new project that will receive €8 million in funding over 5 years,